发明申请
- 专利标题: METHOD AND APPARATUS FOR MEASURING LONG BONE DENSITY OF SMALL-ANIMALS
- 专利标题(中): 用于测量小动物长骨密度的方法和装置
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申请号: US12204132申请日: 2008-09-04
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公开(公告)号: US20090080608A1公开(公告)日: 2009-03-26
- 发明人: Douglas L. Vizard , Douglas O. Wood , William E. McLaughlin , Gilbert Feke , Rao Papineni
- 申请人: Douglas L. Vizard , Douglas O. Wood , William E. McLaughlin , Gilbert Feke , Rao Papineni
- 主分类号: G01N23/06
- IPC分类号: G01N23/06
摘要:
A method and apparatus are disclosed for measuring long bone density of small animals. A phosphor screen or plate is provided of a type that transduces incident ionizing radiation to emitted light. A small animal is positioned before the phosphor screen or plate and exposed to soft X-radiation having an energy level in the range of 11 to 16 Kev. Light emitted by the phosphor screen or plate is captured using a digital camera and a digital X-ray image is prepared of a long bone of the animal. The X-ray image is transformed into an X-ray density image and a region of interest is defined on the long bone in the X-ray density image. At least one row of pixels is scanned within the region of interest of the X-ray density image. A nonlinear least squares analysis of data obtained from the scanning step is conducted using a cylindrical model for the long bone within the region of interest.