A precision sense amplifier apparatus includes a current source configured to introduce an adjustable reference current through a reference leg; a current mirror configured to mirror the reference current to a data leg, the data leg selectively coupled to a programmable resistance memory element; an active clamping device coupled to the data leg, and configured to clamp a fixed voltage across the memory element, thereby establishing a fixed current sinking capability thereof; and a differential sense amplifier having a first input thereof coupled to the data leg and a second input thereof coupled to the reference leg; wherein an output of the differential sense amplifier assumes a first logic state whenever the reference current is less than the fixed current sinking capability of the memory element, and assumes a second logic state whenever the reference current exceeds the fixed current sinking capability.