发明申请
- 专利标题： Processes and Apparatuses for the Production of Crystalline Organic Microparticle Compositions by Micro-Milling and Crystallization on Micro-Seed and Their Use
- 专利标题（中）： 通过微晶种微晶粒化和结晶化生产结晶有机微粒组合物的方法和设备及其应用
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申请号： US12282043申请日： 2007-03-12
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公开(公告)号： US20090087492A1公开(公告)日： 2009-04-02
- 发明人: Brian K. Johnson , Hsien Hsin Tung , Ivan Lee , Aaron S. Cote , Cindy Starbuck , Michael Midler
- 申请人： Brian K. Johnson , Hsien Hsin Tung , Ivan Lee , Aaron S. Cote , Cindy Starbuck , Michael Midler
- 申请人地址： US NJ Rahway
- 专利权人： MERCK & CO., INC.
- 当前专利权人： MERCK & CO., INC.
- 当前专利权人地址： US NJ Rahway
- 国际申请： PCT/US2007/063785 WO 20070312
- 主分类号： A61K9/14
- IPC分类号： A61K9/14 ; C07F9/02 ; A61K31/66
摘要：
The present invention relates to a process, for the production of crystalline particles of an active organic compound The process includes the steps of generating a micro-seed by a wet-milling process and subjecting the micro-seed to a crystallization process. The resulting crystalline particles have a mean particle size of less than about 100 μm. The present invention also provides for a pharmaceutical composition which includes the crystalline particles produced by the method described herein and a pharmaceutically acceptable carrier.
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