A game system and method includes a symbol area having a plurality of symbols in a first orientation. The symbols in one or more pay lines may be compared to predefined payout patterns to determine a first payout. The symbols area and corresponding plurality of symbols may then be rotated to a second orientation or configuration. In the second orientation/configuration, the symbols in the one or more pay lines may be compared again to the predefined payout patterns to determine a second payout. Alternatively or additionally, a pay line and/or a payout pattern may change in response to the rotation. Rotation might only be activated if a rotation symbol is included in the plurality of symbols in the symbol area and/or in particular position in the symbol area. A player might also be permitted to pay for the ability to rotate the symbol area.