Provided is a system and method for controlling synchronization of media and multi-devices for an SMMD media service. The system includes a metadata managing unit and a synchronization controlling unit. The metadata managing unit analyzes ne-media to extract metadata. The synchronization controlling unit constructs a synchronization information table to store control data extracted from the metadata, and controls one or more devices for media reproduction on the basis of the synchronization information table. Optimal connectable devices are mapped according to device attributes and synchronization information extracted from metadata of ne-media and the results are controlled according to the contents of media, thereby maximizing the effect of vivid media reproduction.