Methods and apparatus to manage a bonded digital subscriber line (DSL) service are disclosed. A disclosed example method comprises collecting data representative of bandwidth usage for two or more applications serviced by a bonded set of subscriber lines; analyzing historical activity of the two or more applications based on the collected bandwidth usage data; and selecting a first digital subscriber line (DSL) line profile for a first wire pair in the set of subscriber lines, the set of subscriber lines forming a single DSL communication link.