发明申请
- 专利标题: TRIAZOLOPYRIDAZINES AS KINASE MODULATORS
- 专利标题(中): 三唑吡啶作为激酶调节剂
-
申请号: US12187524申请日: 2008-08-07
-
公开(公告)号: US20090098181A1公开(公告)日: 2009-04-16
- 发明人: Tianbao Lu , Richard Alexander , Richard W. Connors , Maxwell D. Cummings , Robert A. Galemmo , Heather Rae Hufnagel , Dana L. Johnson , Ehab Khalil , Kristi A. Leonard , Thomas P. Markotan , Anna C. Maroney , Jan L. Sechler , Jeremy M. Travins , Robert W. Tuman
- 申请人: Tianbao Lu , Richard Alexander , Richard W. Connors , Maxwell D. Cummings , Robert A. Galemmo , Heather Rae Hufnagel , Dana L. Johnson , Ehab Khalil , Kristi A. Leonard , Thomas P. Markotan , Anna C. Maroney , Jan L. Sechler , Jeremy M. Travins , Robert W. Tuman
- 主分类号: A61F2/04
- IPC分类号: A61F2/04 ; C07D487/04 ; A61K31/5025 ; C12N9/99 ; A61K31/541
摘要:
The invention is directed to triazolopyridazine compounds of Formula I: where R1, R5, R6, R7, R8, and A are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of c-Met, and the use of such compounds to reduce or inhibit kinase activity of c-Met in a cell or a subject, and modulate c-Met expression in a cell or subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to c-Met. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.
公开/授权文献
- US08173654B2 Triazolopyridazine compounds 公开/授权日:2012-05-08