发明申请
US20090099218A1 SYNTHESIS OF NOVEL TUBULIN POLYMERIZATION INHIBITORS: BENZOYLPHENYLUREA (BPU) SULFUR ANALOGS
审中-公开
新型管状体聚合抑制剂的合成：苯甲酰基苯酚（BPU）硫化物类似物
- 专利标题： SYNTHESIS OF NOVEL TUBULIN POLYMERIZATION INHIBITORS: BENZOYLPHENYLUREA (BPU) SULFUR ANALOGS
- 专利标题（中）： 新型管状体聚合抑制剂的合成：苯甲酰基苯酚（BPU）硫化物类似物
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申请号： US12211492申请日： 2008-09-16
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公开(公告)号： US20090099218A1公开(公告)日： 2009-04-16
- 发明人: Saeed R. Khan , Gurulingappa Hallur , Manuel Hidalgo , Antonio Jimeno
- 申请人： Saeed R. Khan , Gurulingappa Hallur , Manuel Hidalgo , Antonio Jimeno
- 主分类号： A61K31/505
- IPC分类号： A61K31/505 ; C07D239/38 ; A61K31/513 ; C07D239/34 ; A61P35/00
摘要：
This invention provides a series of BPU analogues; their synthesis and evaluated biological activity. BPU sulfur analogues were found to possess up to 20 fold increased potency, when compared to compound 1, in various cancerous cell lines.
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