The examples described herein provide methods and equipment for an anti-oxidation spraying on a steel billet. In some examples, when the billet at the temperature of 400° C.-1000° C. enters the predetermined spraying region, a plurality of anti-oxidation spraying devices are used to perform an anti-oxidation spray on the billet in two or more directions, thereby forming directly an anti-oxidation coating on the steel billet at 400° C.-1000° C. By using the example method and equipment described herein, on-line spraying of anti-oxidation coating on the steel billet can be performed under high-temperature condition, thereby reducing an oxidation burning loss rate of the steel billet.