发明申请
- 专利标题： Novel lapachone compounds and methods of use thereof
- 专利标题（中）： 新型lapachone化合物及其使用方法
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申请号： US11894900申请日： 2007-08-21
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公开(公告)号： US20090105166A1公开(公告)日： 2009-04-23
- 发明人: Mark A. Ashwell , Manish Tandon , Jean-Marc Lapierre , Syed Ali , David Vensel , Chiang J. Li
- 申请人： Mark A. Ashwell , Manish Tandon , Jean-Marc Lapierre , Syed Ali , David Vensel , Chiang J. Li
- 主分类号： A61K31/704
- IPC分类号： A61K31/704 ; C07D497/10 ; C07D327/06 ; A61K31/55 ; A61K31/438 ; A61K31/39 ; A61K31/4535 ; A61K31/4196 ; A61K31/5377 ; A61P35/00 ; A61K31/44 ; A61K31/517 ; A61K31/566 ; A61K31/337 ; A61K31/675 ; A61K31/7068 ; A61K31/505 ; A61K31/519 ; A61K31/4375
摘要：
The present invention provides novel tricyclic spiro-oxathiine naphthoquinone derivatives, a synthetic method for making the derivatives, and the use of the derivatives to induce cell death and/or to inhibit proliferation of cancer or precancerous cells. The naphthoquinone derivatives of the present invention are related to the compound known as β-lapachone (3,4-dihydro-2,2-dimethyl-2H-naphtho(1,2-b)pyran-5,6-dione).
公开/授权文献
- US07902354B2 Lapachone compounds and methods of use thereof 公开/授权日：2011-03-08
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