An adaptive capacitive touch sense control circuit includes a voltage buffer, a current setting resistor, a current mirror, a capacitor, a start comparator, an end comparator and a time-to-digital converter. The capacitor is connected with the current setting resistor. The circuit further includes a latch with a first control switch and a second control switch. The current setting resistor is switched between the ground and a voltage source through a switching element, so that when the current setting resistor is grounded, the first control switch is closed and the second control switch is opened, and when the current setting resistor is connected with the voltage source, the second control switch is closed and the first control switch is opened. An adaptive charging mode is adopted to sense a capacitance variation with a great ability of interference recognition, a simple structure, low power consumption and real time processing.