发明申请
US20090111867A1 INDOLE ACETIC ACIDS EXHIBITING CRTH2 RECEPTOR ANTAGONISM AND USES THEREOF
失效
表达乙酸显示CRTH2受体拮抗剂及其用途
- 专利标题： INDOLE ACETIC ACIDS EXHIBITING CRTH2 RECEPTOR ANTAGONISM AND USES THEREOF
- 专利标题（中）： 表达乙酸显示CRTH2受体拮抗剂及其用途
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申请号： US12336274申请日： 2008-12-16
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公开(公告)号： US20090111867A1公开(公告)日： 2009-04-30
- 发明人: Youssef L. Bennani , Lawrence Nathan Tumey , Elizabeth Ann Gleason , Michael Joseph Robarge
- 申请人： Youssef L. Bennani , Lawrence Nathan Tumey , Elizabeth Ann Gleason , Michael Joseph Robarge
- 申请人地址： US NJ Madison
- 专利权人： Wyeth
- 当前专利权人： Wyeth
- 当前专利权人地址： US NJ Madison
- 主分类号： A61K31/4035
- IPC分类号： A61K31/4035 ; C07D403/04 ; A61P11/06 ; A61P11/00
摘要：
The invention relates to indole acetic acid compounds which function as antagonists of the CRTH2 receptor. The invention also relates to the use of these compounds to inhibit the binding of prostaglandin D2 and its metabolites or certain thromboxane metabolites to the CRTH2 receptor and to treat disorders responsive to such inhibition.