发明申请
US20090117119A1 RTEF-1 VARIANTS AND THE USE THEREOF FOR INHIBITION OF ANGIOGENESIS
有权
RTEF-1变体及其抑制血管生成的用途
- 专利标题： RTEF-1 VARIANTS AND THE USE THEREOF FOR INHIBITION OF ANGIOGENESIS
- 专利标题（中）： RTEF-1变体及其抑制血管生成的用途
-
申请号： US12134626申请日： 2008-06-06
-
公开(公告)号： US20090117119A1公开(公告)日： 2009-05-07
- 发明人: J. Timothy Stout , Trevor J. McFarland , Binoy Appukuttan
- 申请人： J. Timothy Stout , Trevor J. McFarland , Binoy Appukuttan
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C12N15/12 ; C07K14/47 ; C12N15/85 ; A61K31/711 ; A61K38/17 ; A61K39/395 ; A61K35/76 ; A61P35/00 ; A61P35/04 ; A61P27/02 ; C12N15/861 ; C12N15/869 ; C12N15/867 ; C12N15/86
摘要：
Dominant negative (DN) variants of transcriptional enhancer factor 1-related (RTEF-1) are described. DN RTEF-1 polypeptides may be directly targeted to cells or delivered in nucleic acid expression vectors to alter cellular transcription. Methods for inhibiting VEGF production and thereby treating angiogenic disorders such as cancer are described. For example, in certain aspects, DN RTEF-1 may be used to treat angiogenic disorders of the eye such as age related macular degeneration (AMD).
公开/授权文献
信息查询
