发明申请
US20090118265A1 NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONANE DERIVATIVES AND THEIR MEDICAL USE
审中-公开
新的1,4-二氮杂双环[3.2.2]非衍生物及其医学用途
![NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONANE DERIVATIVES AND THEIR MEDICAL USE](/docs/US/2009-05-07/US20090118265A1/abs.jpg.600x600.jpg)
- 专利标题： NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONANE DERIVATIVES AND THEIR MEDICAL USE
- 专利标题（中）： 新的1,4-二氮杂双环[3.2.2]非衍生物及其医学用途
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申请号： US12300010申请日： 2007-05-21
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公开(公告)号： US20090118265A1公开(公告)日： 2009-05-07
- 发明人: Dan Peters , Gunnar M. Olsen , Elsebet Ostergaard Nielsen , Daniel B. Timmermann , Steven Charles Loechel , Jeppe Kejser Christensen , Tino Dyhring
- 申请人： Dan Peters , Gunnar M. Olsen , Elsebet Ostergaard Nielsen , Daniel B. Timmermann , Steven Charles Loechel , Jeppe Kejser Christensen , Tino Dyhring
- 优先权： DKPA200600704 20060523
- 国际申请： PCT/EP07/54869 WO 20070521
- 主分类号： A61K31/5513
- IPC分类号： A61K31/5513 ; C07D471/08 ; A61P17/00 ; A61P17/10 ; A61P15/12 ; A61P15/10 ; A61P15/06 ; A61P11/06 ; A61P1/06 ; A61P1/00 ; A61P25/14 ; A61P25/24 ; A61P25/18 ; A61P25/22 ; A61P25/06 ; A61P25/28 ; A61P25/00 ; A61P25/36 ; A61P25/34 ; A61P25/32 ; A61P9/12 ; A61P17/06 ; A61P25/16 ; A61P3/04
![NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONANE DERIVATIVES AND THEIR MEDICAL USE](/abs-image/US/2009/05/07/US20090118265A1/abs.jpg.150x150.jpg)
摘要：
This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonane derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.