发明申请
US20090118272A1 BENZOTHIAZOLE AND AZABENZOTHIAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS
有权
苯并噻唑和亚苄基唑类化合物作为激酶抑制剂有用
- 专利标题: BENZOTHIAZOLE AND AZABENZOTHIAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS
- 专利标题(中): 苯并噻唑和亚苄基唑类化合物作为激酶抑制剂有用
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申请号: US12333425申请日: 2008-12-12
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公开(公告)号: US20090118272A1公开(公告)日: 2009-05-07
- 发明人: Chunjian Liu , Katerina Leftheris , James Lin
- 申请人: Chunjian Liu , Katerina Leftheris , James Lin
- 专利权人: Bristol-Myers Squibb Company
- 当前专利权人: Bristol-Myers Squibb Company
- 主分类号: A61K31/428
- IPC分类号: A61K31/428 ; C07D417/14 ; C07D417/10 ; A61K31/5377 ; A61K31/4439 ; A61P29/00 ; A61K31/454 ; A61K31/437 ; C07D513/04
摘要:
A compound of Formula (I) an enantiomer, diastereomer or a pharmaceutically-acceptable salt thereof, wherein A is independently selected from: further wherein R1, R2, R3, R4, R5, R6, R7, and W are as described herein.Also disclosed is a compound of Formula (II) an enantiomer, diastereomer, or a pharmaceutically-acceptable salt thereof, wherein each of G, X and Y are independently CH or N, wherein at each occurrence at least one of G, X or Y is N and the other two of G, X or Y are CH; and B is independently selected from: further wherein R1, R2, R3, R4, R5, R8, R9 and Z are as described herein.Also disclosed are pharmaceutical compositions containing compounds of Formula (I) and Formula (II), and methods of treating conditions associated with the activity of p38 kinase.
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