发明申请
- 专利标题： Compounds and Compositions as Protein Kinase Inhibitors
- 专利标题（中）： 化合物和组合物作为蛋白激酶抑制剂
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申请号： US11914308申请日： 2006-05-10
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公开(公告)号： US20090118273A1公开(公告)日： 2009-05-07
- 发明人: Advait Nagle , Nathanael Schiander Gray , Yi Liu , Pingda Ren , Taebo Sim , Shuli You
- 申请人： Advait Nagle , Nathanael Schiander Gray , Yi Liu , Pingda Ren , Taebo Sim , Shuli You
- 国际申请： PCT/US06/18096 WO 20060510
- 主分类号： A61K31/519
- IPC分类号： A61K31/519 ; C07D487/04 ; C07D413/14 ; A61K31/496 ; A61P35/00 ; A61K31/5377 ; C07D403/14
摘要：
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of Abl, Bcr-Abl, Bmx, BTK, b-RAF, c RAF, CSK, cSRC, Fes, FGFR3, Flt3, IKKα, IKKβ, JNK1α1, JNK2α2, Lck, Met, MKK4, MKK6, p70S6K, PAK2, PDGFRα, PKA, PKCα, PKD2, ROCK-II, Ros, Rsk1, SAPK2α, SAPK2β, SAPK3, SAPK4, SGK, Syk, Tie2 and TrkB kinases.