发明申请
US20090118514A1 PROCESSES FOR PREPARING PIOGLITAZONE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS
审中-公开
制备PIOGLITAZONE及其药物接受口服的方法
- 专利标题： PROCESSES FOR PREPARING PIOGLITAZONE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS
- 专利标题（中）： 制备PIOGLITAZONE及其药物接受口服的方法
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申请号： US12265142申请日： 2008-11-05
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公开(公告)号： US20090118514A1公开(公告)日： 2009-05-07
- 发明人: Raghupathi Reddy Anumula , Goverdhan Gilla , Lokeswara Rao Madivada , Prabhakar Macharla , Kavitha Charagondla
- 申请人： Raghupathi Reddy Anumula , Goverdhan Gilla , Lokeswara Rao Madivada , Prabhakar Macharla , Kavitha Charagondla
- 优先权： IN2555/CHE/2007 20071106
- 主分类号： C07D417/12
- IPC分类号： C07D417/12
摘要：
An improved process for the preparation of pioglitazone and its pharmaceutically acceptable salts by reducing 5-[4-[2-(5-ethyl-2-pyridyl)ethoxy]benzilidene]-2,4-thiazolidinedione with sodium borohydride in presence of a cobalt ion and dimethyl glyoxime. More particularly the cobalt ion used is cobalt chloride hexahydrate, or, cobalt (II) nitrate hexahydrate in presence of mixture of DMF and water as solvents.
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