发明申请
US20090124023A1 Reagens for the Detection of Protein Acetylation Signaling Pathways
审中-公开
用于检测蛋白质乙酰化信号通路的试剂
- 专利标题: Reagens for the Detection of Protein Acetylation Signaling Pathways
- 专利标题(中): 用于检测蛋白质乙酰化信号通路的试剂
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申请号: US12227321申请日: 2007-05-11
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公开(公告)号: US20090124023A1公开(公告)日: 2009-05-14
- 发明人: Ailan Guo , Ting-Lei Gu , Jeffrey Mitchell , Peter Hornbeck
- 申请人: Ailan Guo , Ting-Lei Gu , Jeffrey Mitchell , Peter Hornbeck
- 国际申请: PCT/US2007/011444 WO 20070511
- 主分类号: G01N33/566
- IPC分类号: G01N33/566 ; C07K16/18
摘要:
The invention discloses 432 novel acetylation sites identified in signal transduction proteins and pathways underlying human protein acetylation signaling pathways, and provides acetylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these acetylated sites/proteins, as well as methods of using the reagents for such purpose. Among the acetylation sites identified are sites occurring in the following protein types: Acetyltransferases, Adaptor/Scaffold proteins, Actin binding proteins, Adhesion proteins, Apoptosis proteins, Calcium-binding proteins, Cell Cycle Regulation proteins, Cell Surface proteins, DNA binding proteins, DNA replication proteins, Channel proteins, Chaperone proteins, Cellular Metabolism enzymes, Cytoskeletal proteins, DNA repair proteins, Endoplasmic reticulum proteins, Enzyme proteins, G protein and GTPase Activating proteins, Guanine Nucleotide Exchange Factors, Helicase proteins, Isomerase proteins, Extracelluar matrix proteins, Hydrolases, Ligase proteins, Lipid kinases, Inhibtor proteins, Lipid Binding proteins and Lyases.