发明申请
US20090124660A1 Piperidine Compounds Useful as Malonyl-CoA Decarboxylase Inhibitors
有权
可用作丙二酰辅酶A脱羧酶抑制剂的哌啶化合物
- 专利标题： Piperidine Compounds Useful as Malonyl-CoA Decarboxylase Inhibitors
- 专利标题（中）： 可用作丙二酰辅酶A脱羧酶抑制剂的哌啶化合物
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申请号： US12245558申请日： 2008-10-03
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公开(公告)号： US20090124660A1公开(公告)日： 2009-05-14
- 发明人: Jie Fei Cheng , Mi Chen , Thomas Arrhenius , Mark E. Wilson , Gary D. Lopaschuk , Jason R. Dyck , Rossy Serafimov
- 申请人： Jie Fei Cheng , Mi Chen , Thomas Arrhenius , Mark E. Wilson , Gary D. Lopaschuk , Jason R. Dyck , Rossy Serafimov
- 申请人地址： JP Tokyo
- 专利权人： CHUGAI SEIYAKU KABUSHIKI KAISHA
- 当前专利权人： CHUGAI SEIYAKU KABUSHIKI KAISHA
- 当前专利权人地址： JP Tokyo
- 主分类号： A61K31/454
- IPC分类号： A61K31/454 ; C07D417/12
摘要：
The present invention provides methods for the use of compounds as depicted by structure I, pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway. In particular, these compounds and pharmaceutical composition containing the same are indicated in the prophylaxis, management and treatment of cardiovascular diseases, diabetes, cancer and obesity.
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