发明申请
- 专利标题： MRI CONTRAST MEDIUM CONTAINING LIPOSOMES
- 专利标题（中）： MRI对比中药含有脂质体
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申请号： US11916391申请日： 2006-06-06
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公开(公告)号： US20090130022A1公开(公告)日： 2009-05-21
- 发明人: Junji Nishigaki , Hiroyuki Hirai , Masayoshi Kojima , Kazuhiro Aikawa
- 申请人： Junji Nishigaki , Hiroyuki Hirai , Masayoshi Kojima , Kazuhiro Aikawa
- 申请人地址： JP Tokyo
- 专利权人： FUJIFILM Corporation
- 当前专利权人： FUJIFILM Corporation
- 当前专利权人地址： JP Tokyo
- 优先权： JP2005-165722 20050606
- 国际申请： PCT/JP2006/311701 WO 20060606
- 主分类号： A61B5/055
- IPC分类号： A61B5/055 ; A61K9/127
摘要：
A liposome containing a phosphatidylcholine and a phosphatidylserine in combination as membrane components at a phosphatidylcholine:phosphatidylserine molar ratio of 3:1 to 1:2, and said liposome containing superparamagnetic particles having a mean particle size not less than 1 nm and not more than 50 nm. A means for selectively accumulating an MRI contrast medium in a lesion of a vascular disease caused by abnormal proliferation of vascular smooth muscle cells such as arteriosclerosis and restenosis after PTCA is provided.