发明申请
- 专利标题： Activation of HCV-specific T cells
- 专利标题（中）： HCV特异性T细胞的激活
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申请号： US11974958申请日： 2007-10-17
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公开(公告)号： US20090130762A1公开(公告)日： 2009-05-21
- 发明人: Xavier Paliard , Michael Houghton , Mark Selby
- 申请人： Xavier Paliard , Michael Houghton , Mark Selby
- 主分类号： C12N15/87
- IPC分类号： C12N15/87 ; C12N5/06
摘要：
The invention provides a method of activating hepatitis C virus (HCV)-specific T cells, including CD4+ and CD8+ T cells. HCV-specific T cells are activated using fusion proteins comprising HCV NS3, NS4, NS5a, and NS5b polypeptides, polynucleotides encoding such fusion proteins, or polypeptide or polynucleotide compositions containing the individual components of these fusions. The method can be used in model systems to develop HCV-specific immunogenic compositions, as well as to immunize a mammal against HCV.
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