发明申请
- 专利标题： Thienopyrazole Derivative Having PDE7 Inhibitory Activity
- 专利标题（中）： 具有PDE7抑制活性的噻吩衍生物
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申请号： US11630757申请日： 2005-07-01
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公开(公告)号： US20090131413A1公开(公告)日： 2009-05-21
- 发明人: Hidekazu Inoue , Hidenobu Murafuji , Yasuhiro Hayashi
- 申请人： Hidekazu Inoue , Hidenobu Murafuji , Yasuhiro Hayashi
- 申请人地址： JP Tokyo
- 专利权人： ASUBIO PHARMA CO., LTD.
- 当前专利权人： ASUBIO PHARMA CO., LTD.
- 当前专利权人地址： JP Tokyo
- 优先权： JP2004-195836 20040701
- 国际申请： PCT/JP2005/012208 WO 20050701
- 主分类号： A61K31/4162
- IPC分类号： A61K31/4162 ; C07D495/04 ; A61K31/551 ; A61K31/496 ; A61K31/454 ; C07D231/14 ; C07D231/18 ; A61K31/4188 ; A61K31/4439 ; A61K31/5377 ; A61K31/438
摘要：
To provide thienopyrazole derivatives inhibiting PDE 7 selectively, and therefore, enhance cellular cAMP level. Consequently, the compound is useful for treating various kinds of disease such as allergic diseases, inflammatory diseases or immunologic diseases. The compound is thienopyrazole compound represented by the following formula (I): [wherein, especially, R1 is a cyclohexyl, a cycloheptyl group or a tetrahydropyranyl group; R2 is methyl; R3 is a hydrogen atom; and R4 is a group: —CONR5R6 (in which any one of R5 and R6 is a hydrogen atom)].
公开/授权文献
- US07932250B2 Thienopyrazole derivative having PDE7 inhibitory activity 公开/授权日：2011-04-26