发明申请
- 专利标题： Heterocycle Compound, and Production Process and Application Thereof
- 专利标题（中）： 杂环化合物及其制备方法及应用
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申请号： US11991858申请日： 2006-09-15
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公开(公告)号： US20090131467A1公开(公告)日： 2009-05-21
- 发明人: Hashime Kanazawa , Tomoji Aotsuka , Kentarou Kumazawa , Kouki Ishitani , Takashi Nose
- 申请人： Hashime Kanazawa , Tomoji Aotsuka , Kentarou Kumazawa , Kouki Ishitani , Takashi Nose
- 优先权： JP2005-268527 20050915
- 国际申请： PCT/JP2006/318348 WO 20060915
- 主分类号： A61K31/437
- IPC分类号： A61K31/437 ; C07D471/04 ; A61P11/06 ; A61P11/00
摘要：
The compound of the present invention is a novel compound which has a specific heterocycle skeleton, particularly a pyrazolonaphthyridine or pyrazoloquinoline skeleton having an organic group (e.g., a carbocycle and a heterocycle) bonding through an alkylene group at 3-position and a carbocycle bonding at 5-position and has a phosphodiesterase IV inhibitory activity. At least one of the ring (the carbocycle or the heterocycle) bonding at 3-position of the pyrazolonaphthyridine skeleton and the carbocycle bonding at 5-position may have a halogenated alkyl group and/or a halogenated alkoxy group as a substituent. Such a compound or a salt thereof is useful as a phosphodiesterase IV inhibitor and the like. According to the present invention, a novel compound having a high phosphodiesterase IV inhibitory effect can be provided.