发明申请
US20090136549A1 TRANSDERMAL PATCH CONTAINING RASAGILINE FOR TREATMENT OR PROPHYLAXIS OF NERVOUS SYSTEM DISEASE AND ITS PREPARATION PROCESS
审中-公开
含有RASAGILINE用于治疗或预防神经系统疾病及其制备过程的透皮贴
- 专利标题: TRANSDERMAL PATCH CONTAINING RASAGILINE FOR TREATMENT OR PROPHYLAXIS OF NERVOUS SYSTEM DISEASE AND ITS PREPARATION PROCESS
- 专利标题(中): 含有RASAGILINE用于治疗或预防神经系统疾病及其制备过程的透皮贴
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申请号: US12281875申请日: 2007-03-06
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公开(公告)号: US20090136549A1公开(公告)日: 2009-05-28
- 发明人: Jialiang Lin , Jinmai Xiao , Jie Deng
- 申请人: Jialiang Lin , Jinmai Xiao , Jie Deng
- 申请人地址: CN Chongqing CN SHANGHAI
- 专利权人: Chongqing Pharmaceutical Research Institute Co., Ltd.,SHANGHAI FOSUN PHARMACEUTICAL (GROUP) CO., LTD
- 当前专利权人: Chongqing Pharmaceutical Research Institute Co., Ltd.,SHANGHAI FOSUN PHARMACEUTICAL (GROUP) CO., LTD
- 当前专利权人地址: CN Chongqing CN SHANGHAI
- 优先权: CN200310054110.1 20060306
- 国际申请: PCT/CN07/00713 WO 20070306
- 主分类号: A61K9/00
- IPC分类号: A61K9/00 ; A61K31/136 ; A61P25/28
摘要:
The present invention relates to a rasagiline transdermal patch for treatment or prophylaxis of nervous system diseases, in which the patch comprises an inert backing layer chemically inert to substrate ingredients, a substrate layer comprising rasagiline or a pharmaceutically acceptable salt thereof, and a protective layer to be peeled off before use. The substrate layer is an adhesive system comprising an organic polymer material as basis and an inorganic or organic material as filler, and a plurality of micro-reservoirs containing rasagiline. The substrate further comprises one or more substances for enhancing the transdermal absorption of rasagiline, in which the above organic polymer material in the substrate is used for the reservoir of rasagiline and as adhesive.
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