发明申请
US20090137785A1 RAB9 PROTEIN CRYSTAL STRUCTURES AND METHODS FOR IDENTIFYING RAB9 MODULATORS
审中-公开
RAB9蛋白晶体结构和识别RAB9调节剂的方法
- 专利标题： RAB9 PROTEIN CRYSTAL STRUCTURES AND METHODS FOR IDENTIFYING RAB9 MODULATORS
- 专利标题（中）： RAB9蛋白晶体结构和识别RAB9调节剂的方法
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申请号： US11933636申请日： 2007-11-01
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公开(公告)号： US20090137785A1公开(公告)日： 2009-05-28
- 发明人: Edward J. Meehan , Liqing Chen , Enrico L. DiGiammarino , Thomas W. Hodge
- 申请人： Edward J. Meehan , Liqing Chen , Enrico L. DiGiammarino , Thomas W. Hodge
- 申请人地址： US AL Hunstsville
- 专利权人： THE UNIVERSITY OF ALABAMA IN HUNTSVILLE
- 当前专利权人： THE UNIVERSITY OF ALABAMA IN HUNTSVILLE
- 当前专利权人地址： US AL Hunstsville
- 主分类号： C07K14/00
- IPC分类号： C07K14/00
摘要：
The present invention relates to crystalline Rab9 in complex with either GDP or the GTP analog Guanosine 5′-(β,γ-imido) triphosphate (GppNHp), the three dimensional coordinates and structures of Rab9 in Rab9-GDP and Rab9-GppNHp complexes, and uses thereof for drug design. In particular, the present invention relates to methods for producing Rab9 crystals of sufficient quality to obtain a determination of the three dimensional structure of Rab9 to a high resolution in both its GTP-bound (on/active) and GDP-bound (off/inactive) conformations. The present invention also relates to a computer-readable medium encoded with the three dimensional coordinates of Rab9 in Rab9-GDP and Rab9-GppNHp complexes wherein, using a graphical display software program, the three dimensional coordinates create an electronic file that can be visualized on a computer capable of representing the electronic file as a three dimensional image.
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