发明申请
- 专利标题： HUMAN ANTIBODIES TO HUMAN DELTA LIKE LIGAND 4
- 专利标题（中）： 人类抗体与人类三角形配对4
-
申请号： US12371159申请日： 2009-02-13
-
公开(公告)号： US20090142354A1公开(公告)日： 2009-06-04
- 发明人: Nicholas J. Papadopoulos , Joel H. Martin , Eric Smith , Irene Noguera-Troise , Gavin Thurston
- 申请人： Nicholas J. Papadopoulos , Joel H. Martin , Eric Smith , Irene Noguera-Troise , Gavin Thurston
- 申请人地址： US NY Tarrytown
- 专利权人： Regeneron Pharmaceuticals, Inc.
- 当前专利权人： Regeneron Pharmaceuticals, Inc.
- 当前专利权人地址： US NY Tarrytown
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/18
摘要：
An isolated human antibody or a fragment of a human antibody which specifically binds to human delta-like ligand 4 (hDll4) and blocks hDll4 binding to a Notch receptor. The human anti-hDll4 antibody or antibody fragment binds dimeric hDll4 with an affinity of 75 pM or better, as measured by surface plasmon resonance.
公开/授权文献
- US07534868B1 Human antibodies to human delta like ligand 4 公开/授权日：2009-05-19
信息查询
