发明申请
- 专利标题： ISOXAZOLO-PYRAZINE DERIVATIVES
- 专利标题（中）： ISOXAZOLO-PYRAZINE DORIVATIVES
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申请号： US12277326申请日： 2008-11-25
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公开(公告)号： US20090143407A1公开(公告)日： 2009-06-04
- 发明人: Bernd Buettelmann , Roland Jakob-Roetne , Henner Knust , Andrew Thomas
- 申请人： Bernd Buettelmann , Roland Jakob-Roetne , Henner Knust , Andrew Thomas
- 优先权： EP07122271.5 20071204
- 主分类号： A61K31/497
- IPC分类号： A61K31/497 ; C07D413/02
摘要：
The invention relates to isoxazolo-pyrazine derivatives and their pharmaceutically acceptable salts having affinity and selectivity for the GABA A α5 receptor binding site, their manufacture, and pharmaceutical compositions containing them. The compounds of present invention are inverse agonists of GABA A α5. The invention also relates to methods for enhancing cognition and for treating cognitive disorders like Alzheimer's disease.
公开/授权文献
- US07618973B2 Isoxazolo-pyrazine derivatives 公开/授权日：2009-11-17
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