发明申请
- 专利标题: EP4 RECEPTOR ANTAGONISTS
- 专利标题(中): EP4受体拮抗剂
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申请号: US12360954申请日: 2009-01-28
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公开(公告)号: US20090143437A1公开(公告)日: 2009-06-04
- 发明人: Alexander W. Oxford , Richard J. Davis , Robert A. Coleman , Kenneth L. Clark , David E. Clark , Neil V. Harris , Garry Fenton , George Hynd , Keith A.J. Stuttle , Jonathan M. Sutton , Christopher G. Newton
- 申请人: Alexander W. Oxford , Richard J. Davis , Robert A. Coleman , Kenneth L. Clark , David E. Clark , Neil V. Harris , Garry Fenton , George Hynd , Keith A.J. Stuttle , Jonathan M. Sutton , Christopher G. Newton
- 申请人地址: GB Hertfordshire
- 专利权人: ASTERAND UK LIMITED
- 当前专利权人: ASTERAND UK LIMITED
- 当前专利权人地址: GB Hertfordshire
- 优先权: GB0302094.8 20030129
- 主分类号: A61K31/341
- IPC分类号: A61K31/341 ; A61K31/422 ; A61K31/443 ; A61P25/00
摘要:
Compounds of formula (X): wherein: R2 is H or an optionally substituted C1-4 alkyl group; Y is either —(CH2)n—X—, where n is 1 or 2 and X is O, S, S(═O), S(═O)2, or NRN1, where RN1 is selected from H or optionally substituted C1-4 alkyl, or Y is —C(═O)NRN2—, where RN2 is selected from H, and optionally substituted C1-7 alkyl or C5-20 aryl; R3 is an optionally substituted C6 aryl group linked to a further optionally substituted C6 aryl group, wherein if both C6 aryl groups are benzene rings, there may be an oxygen bridge between the two rings, bound adjacent the link on both rings; A is a single bond or a C1-3 alkylene group; and R5 is either: (i) carboxy; (ii) a group of formula (II): or (iii) a group of formula (III): wherein R is optionally substituted C1-7 alkyl, C5-20 aryl or NRN3RN4, where RN3 and RN4 are independently selected from optionally substituted alkyl; (iv) tetrazol-5-yl.
公开/授权文献
- US07858644B2 EP4 receptor antagonists 公开/授权日:2010-12-28