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发明申请
US20090149397A1 TREATMENT OF CANCER WITH COMBINATIONS OF TOPOISOMERASE INHIBITORS AND PARP INHIBITORS 审中-公开
用TOPOISOMERASE抑制剂和PARP抑制剂联合治疗癌症

TREATMENT OF CANCER WITH COMBINATIONS OF TOPOISOMERASE INHIBITORS AND PARP INHIBITORS
摘要：
In one aspect, the present invention provides a composition and a kit comprising a combination of topoisomerase inhibitor and PARP inhibitor for treatment of cancer. In another aspect, the invention provides a method of treating cancer comprising administering to a subject a combination of topoisomerase inhibitor and PARP inhibitor. In particular, the invention provides compositions and methods for treating cancer in a subject by inhibiting a poly-ADP-ribose polymerase and a topoisomerase, as well as providing formulations and modes of administering such compositions.
摘要（中）：

一方面，本发明提供了包含拓扑异构酶抑制剂和PARP抑制剂的组合的组合物和试剂盒，用于治疗癌症。 另一方面，本发明提供了一种治疗癌症的方法，包括向受试者施用拓扑异构酶抑制剂和PARP抑制剂的组合。 特别地，本发明提供了通过抑制聚-ADP-核糖聚合酶和拓扑异构酶来治疗受试者的癌症的组合物和方法，以及提供给药这些组合物的制剂和方式。

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