利索-全球专利检索

  1. 登录
  2. 注册
发明申请
US20090149407A1 RNA INTERFERENCE MEDIATED TREATMENT OF ALZHEIMER'S DISEASE USING SHORT INTERFERING NUCLEIC ACID (siNA) 有权
使用短暂干扰核酸（siNA）的RNA干扰介导的治疗阿尔茨海默病

RNA INTERFERENCE MEDIATED TREATMENT OF ALZHEIMER'S DISEASE USING SHORT INTERFERING NUCLEIC ACID (siNA)
摘要：
The present invention concerns methods and reagents useful in modulating BACE gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against beta-secretase (BACE), amyloid precursor protein (APP), pin-1, presenillin 1 (PS-1) and/or presenillin 2 (PS-2) gene expression and/or activity. The small nucleic acid molecules are useful in the treatment of Alzheimer's disease and any other condition that responds to modulation of BACE, APP, pin-1, PS-1 and/or PS-2 expression or activity.
摘要（中）：

本发明涉及可用于调节多种应用中的BACE基因表达的方法和试剂，包括用于治疗，诊断，靶标验证和基因组发现应用。 具体而言，本发明涉及小核酸分子，如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短发夹RNA（shRNA） 能够介导针对β-分泌酶（BACE）的RNA干扰（RNAi），淀粉样蛋白前体蛋白（APP），pin-1，presenillin 1（PS-1）和/或presenillin 2（PS-2）基因表达和/或 活动。 小核酸分子可用于治疗阿尔茨海默病和任何其他对BACE，APP，pin-1，PS-1和/或PS-2表达或活性的调节作出反应的条件。

公开/授权文献
信息查询
Global Dossier Espacenet
0/0