发明申请
US20090155235A1 AGGREGATES WITH INCREASED DEFORMABILITY, COMPRISING AT LEAST THREE AMPHIPATS, FOR IMPROVED TRANSPORT THROUGH SEMI-PERMEABLE BARRIERS AND FOR THE NON-INVASIVE DRUG APPLICATION IN VIVO, ESPECIALLY THROUGH THE SKIN
审中-公开
累积增加的可变性,包括至少三种AMPHIPATS,通过半渗透性障碍物进行改进的运输,以及通过皮肤特别是非侵入性药物应用
- 专利标题: AGGREGATES WITH INCREASED DEFORMABILITY, COMPRISING AT LEAST THREE AMPHIPATS, FOR IMPROVED TRANSPORT THROUGH SEMI-PERMEABLE BARRIERS AND FOR THE NON-INVASIVE DRUG APPLICATION IN VIVO, ESPECIALLY THROUGH THE SKIN
- 专利标题(中): 累积增加的可变性,包括至少三种AMPHIPATS,通过半渗透性障碍物进行改进的运输,以及通过皮肤特别是非侵入性药物应用
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申请号: US12356381申请日: 2009-01-20
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公开(公告)号: US20090155235A1公开(公告)日: 2009-06-18
- 发明人: Gregor Cevc , Ulrich Vierl
- 申请人: Gregor Cevc , Ulrich Vierl
- 申请人地址: DE Munich
- 专利权人: IDEA AG
- 当前专利权人: IDEA AG
- 当前专利权人地址: DE Munich
- 主分类号: A61K31/122
- IPC分类号: A61K31/122 ; A61K31/192 ; A61K31/196 ; A61K31/485 ; G01N33/48
摘要:
The invention describes combinations of at least three amphipatic substances forming aggregate suspensions in a polar liquid. Judicious choice of system components, which differ at least 2-times to 10-times in solubility, ensures said aggregates to have extended, unusually adaptable surfaces. This is probably due to simultaneous action on said aggregates of at least two more soluble substances amongst said three system components, at least one of which is an active ingredient and preferably a drug; the third component alternatively, can take the role of a drug. The patent further deals with the use of said combinations in pharmaceutical preparations capable of transporting drugs into the body of warm blood creatures. This is made possible by the drug loading capability of said aggregates with the highly flexible and deformable coating, which renders the resulting drug carriers highly adaptable. The patent finally reveals suitable methods and favourable conditions for carrier manufacturing and application.
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