发明申请
US20090163499A1 Imidazole-substituted arylamides as P2X3 and P2X2/3 antagonists
失效
咪唑取代的芳酰胺如P2X3和P2X2 / 3拮抗剂
- 专利标题： Imidazole-substituted arylamides as P2X3 and P2X2/3 antagonists
- 专利标题（中）： 咪唑取代的芳酰胺如P2X3和P2X2 / 3拮抗剂
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申请号： US12316942申请日： 2008-12-17
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公开(公告)号： US20090163499A1公开(公告)日： 2009-06-25
- 发明人: Li Chen , Michael Patrick Dillon , Lichun Feng , Ronald Charles Hawley , Minmin Yang
- 申请人： Li Chen , Michael Patrick Dillon , Lichun Feng , Ronald Charles Hawley , Minmin Yang
- 专利权人： Roche Palo Alto LLC
- 当前专利权人： Roche Palo Alto LLC
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; C07D413/04 ; A61P29/00
摘要：
Compounds of the formula I: wherein R1 is optionally substituted imidazolyl, and R2, R3, R4, R5, R6, R7 and R8 are as defined herein. Also provided are methods of using the compounds for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist and methods of making the subject compounds.
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