A method and apparatus for controlling operation of a communication device is provided. In one embodiment, a mobile phone device includes: a communication section configured to perform radio communication; an operation section including number keys and a call-initiating key; and a control section configured to activate, on the basis of an operation that is performed using the operation section, a call-initiating program or a non-call-initiating program, and depending on what operations are performed by a user using the operation section of the mobile phone device, determining whether to interrupt a currently activated program to initiate a predetermined call with increased ease of use and convenience to the user.