Invention Application
US20090170828A1 Azetidine Derivatives as Inhibitors of Stearoyl-Coenzyme a Delta-9 Desaturase
审中-公开
氮杂环丁烷衍生物作为硬脂酰辅酶Delta-9去饱和酶的抑制剂
- Patent Title: Azetidine Derivatives as Inhibitors of Stearoyl-Coenzyme a Delta-9 Desaturase
- Patent Title (中): 氮杂环丁烷衍生物作为硬脂酰辅酶Delta-9去饱和酶的抑制剂
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Application No.: US12227544Application Date: 2007-06-08
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Publication No.: US20090170828A1Publication Date: 2009-07-02
- Inventor: Elise Isabel , Renata Oballa , David Powell , Joel Robichaud
- Applicant: Elise Isabel , Renata Oballa , David Powell , Joel Robichaud
- International Application: PCT/CA2007/001026 WO 20070608
- Main IPC: A61K31/397
- IPC: A61K31/397 ; C07D277/20 ; C07D403/02 ; C07D401/02 ; A61P3/04 ; A61P3/10 ; A61P9/10
Abstract:
Azetidine derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; liver steatosis; and non-alcoholic steatohepatitis. (I)
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