发明申请
US20090170863A1 Acylated Spiropiperidine Derivatives as Melanocortin-4 Receptor Modulators
有权
酰基化Spiropiperidine衍生物作为黑皮质素-4受体调节剂
- 专利标题： Acylated Spiropiperidine Derivatives as Melanocortin-4 Receptor Modulators
- 专利标题（中）： 酰基化Spiropiperidine衍生物作为黑皮质素-4受体调节剂
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申请号： US11992262申请日： 2006-09-25
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公开(公告)号： US20090170863A1公开(公告)日： 2009-07-02
- 发明人: Tianying Jian , Jian Liu , Ravi P. Nargund
- 申请人： Tianying Jian , Jian Liu , Ravi P. Nargund
- 申请人地址： US NJ Rahway
- 专利权人： MERCK & CO., INC.
- 当前专利权人： MERCK & CO., INC.
- 当前专利权人地址： US NJ Rahway
- 国际申请： PCT/US2006/037196 WO 20060925
- 主分类号： A61K31/438
- IPC分类号： A61K31/438 ; A61K31/501 ; A61K31/497 ; A61K31/506 ; C07D491/147 ; C07D471/10
摘要：
Certain novel N-acylated spiropiperidine derivatives are ligands of the human melanocortin receptor(s) and, in particular, are selective ligands of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of MC-4R, such as obesity, diabetes, nicotine addiction, alcoholism, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.