An electrostatic discharge (ESD) protection circuit electrically connected to a first conductive line and a second conductive line is provided. The ESD protection circuit has a first ESD protection circuit unit, wherein the first ESD circuit unit includes a first coupled capacitor and a first active device. The first coupled capacitor includes a first electrode and a second electrode, wherein the first electrode is electrically connected to the first conductive line. The first active device includes a first gate, a first source and a first drain, wherein the first gate is electrically connected to the second electrode. In addition, the first source and the first electrode are electrically connected to the first conductive line, and the first drain is electrically connected to the second conductive line. Therefore, the conduction efficiency of the ESD protection circuit is improved.