发明申请
- 专利标题： Bicyclic Spirohydantoin CGRP Receptor Antagonists
- 专利标题（中）： 双环螺乙内酰脲CGRP受体拮抗剂
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申请号： US12085005申请日： 2006-11-14
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公开(公告)号： US20090176757A1公开(公告)日： 2009-07-09
- 发明人: Ian M. Bell , Harold G. Selnick , Craig A. Stump , Cory R. Theberge , C. Blair Zartman
- 申请人： Ian M. Bell , Harold G. Selnick , Craig A. Stump , Cory R. Theberge , C. Blair Zartman
- 国际申请： PCT/US06/44194 WO 20061114
- 主分类号： A61K31/554
- IPC分类号： A61K31/554 ; A61K31/553 ; A61K31/5377 ; A61K31/506 ; A61K31/497 ; A61K31/496 ; A61K31/4747
摘要：
Compounds of formula I: (wherein variables A1, A2, A3, A4, A5, A6, A7, B, E1, E2, E3, E4, E5, G1, G2 and R6 are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
公开/授权文献
- US08071771B2 Bicyclic spirohydantoin CGRP receptor antagonists 公开/授权日：2011-12-06
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