Secure content management is enabled as a cloud-based service through which security protection and policy enforcement may be implemented for both on-premise network users and off-premise or roaming users. The global SCM service integrates the security functionalities—such as anti-virus, spyware, and phishing protection, firewall, intrusion detection, centralized management, and the like—that are typically provided by enterprise network SCM appliance hardware or servers into a cloud-based service that users reach via Internet-based points-of-presence (“POPs”). The POPs are configured with forward proxy servers, and in some implementations, caching and network acceleration components, and coupled to hubs which provide configuration management and identity management services such as active directory services.