发明申请
- 专利标题: Oxadiazolidinedione Compound
- 专利标题(中): 恶二唑烷二酮化合物
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申请号: US12298522申请日: 2007-04-23
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公开(公告)号: US20090186909A1公开(公告)日: 2009-07-23
- 发明人: Kenji Negoro , Fumiyoshi Iwasaki , Kei Ohnuki , Toshio Kurosaki , Yasuhiro Yonetoku , Norio Asai , Shigeru Yoshida , Takatoshi Soga
- 申请人: Kenji Negoro , Fumiyoshi Iwasaki , Kei Ohnuki , Toshio Kurosaki , Yasuhiro Yonetoku , Norio Asai , Shigeru Yoshida , Takatoshi Soga
- 优先权: JP2006-118630 20060424
- 国际申请: PCT/JP2007/058694 WO 20070423
- 主分类号: A61K31/506
- IPC分类号: A61K31/506 ; A61K31/4439 ; A61K31/4245 ; C07D413/12 ; C07D271/07
摘要:
[Problem] A compound which can be used as a pharmaceutical, particularly a insulin secretion promoter or a agent for preventing/treating disease in which GPR40 is concerned such as diabetes or the like, is provided.[Means for resolution] It was found that an oxadiazolidinedione compound which is characterized by the possession of a benzyl or the like substituent binding to the cyclic group via a linker at the 2-position of the oxadiazolidinedione ring, or a pharmaceutically acceptable salt thereof, has excellent GPR40 agonist action. In addition, since the oxadiazolidinedione compound of the present invention showed excellent insulin secretion promoting action and blood glucose level-lowering action, it is useful as an insulin secretion promoter or an agent for preventing/treating diabetes.
公开/授权文献
- US07968552B2 Oxadiazolidinedione compound 公开/授权日:2011-06-28
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