- 专利标题： OXAZOLE-PYRROLE-PIPERAZINE ALPHA-HELIX MIMETIC
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申请号： US12362934申请日： 2009-01-30
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公开(公告)号： US20090197895A1公开(公告)日： 2009-08-06
- 发明人: Julius Rebek, JR. , Shannon Biros , Lionel Moisan , Severin Odermatt
- 申请人： Julius Rebek, JR. , Shannon Biros , Lionel Moisan , Severin Odermatt
- 申请人地址： US CA La Jolla
- 专利权人： The Scripps Research Institute
- 当前专利权人： The Scripps Research Institute
- 当前专利权人地址： US CA La Jolla
- 主分类号： A61K31/496
- IPC分类号： A61K31/496 ; C07D413/14 ; C40B40/04
摘要：
Amphiphilic α-helix mimetics are provided. These compounds are constructed using an oxazole-pyrrole-piperazine (OPP) scaffold. The amphiphilic α-helix mimetics are also employable for making libraries and for treating diseases or conditions effected by the inhibition or disruption of interactions with the alpha helix of a protein.