发明申请
- 专利标题： Flavonoid Dimers and Methods of Making and Using Such
- 专利标题（中）： 黄酮类二聚体及其使用方法
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申请号： US12301504申请日： 2007-05-09
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公开(公告)号： US20090197943A1公开(公告)日： 2009-08-06
- 发明人: Tak-Hang Chan , Larry Ming-Cheung Chow
- 申请人： Tak-Hang Chan , Larry Ming-Cheung Chow
- 申请人地址： CN Kowloon CA Montreal
- 专利权人： The Hong Kong Polytechnic University,McGill University
- 当前专利权人： The Hong Kong Polytechnic University,McGill University
- 当前专利权人地址： CN Kowloon CA Montreal
- 国际申请： PCT/IB07/51730 WO 20070509
- 主分类号： A61K31/353
- IPC分类号： A61K31/353 ; C07D405/12 ; A61P43/00
摘要：
Multidrug resistance (MDR) is a major problem in cancer chemotherapy. The best characterized resistance mechanism is the one mediated by the over-expression of drug efflux transporters, permeability-glycoprotein (P-gp), which pump a variety of anticancer drugs out of the cells, resulting in lowered intracellular drug accumulation. A series of flavonoid dimers are developed in this invention, which are linked together by linker groups of various lengths. These flavonoid dimers are found to be efficient P-gp modulators that increase cytotoxicity of anticancer drugs in vitro and dramatically enhance their intracellular drug accumulation. It is found that the flavonoid dimers of this invention is also useful in reducing drug resistance in treating parasitic diseases.
公开/授权文献
- US08710097B2 Flavonoid dimers and methods of making and using such 公开/授权日：2014-04-29
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