Image sensors and methods of operating image sensors. An image sensor includes an array of pixels and an array of color filters disposed over the array of pixels such that each different color filter is disposed over multiple pixels. A method of operating an image sensor including an array of two by two blocks of single color pixels includes determining a level of incident light, determining an incident light value corresponding to the level of incident light and comparing the incident light value to a predetermined threshold value. If the incident light value is less than the predetermined threshold value, a combined signal is read from the two by two blocks. If the incident light value is less than the predetermined threshold value, an individual signal is read from each pixel.