发明申请
- 专利标题: NOVEL ENGINEERED MICROORGANISM PRODUCING HOMO-SUCCINIC ACID AND METHOD FOR PREPARING SUCCINIC ACID USING THE SAME
- 专利标题(中): 生产同型酸的新型工程化微生物及其制备方法
-
申请号: US12359322申请日: 2009-01-25
-
公开(公告)号: US20090203095A1公开(公告)日: 2009-08-13
- 发明人: Sang Yup LEE , Sung Won LIM , Hyohak SONG
- 申请人: Sang Yup LEE , Sung Won LIM , Hyohak SONG
- 申请人地址: KR Daejeon
- 专利权人: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
- 当前专利权人: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
- 当前专利权人地址: KR Daejeon
- 优先权: KR10-2006-0071666 20060728
- 主分类号: C12P7/46
- IPC分类号: C12P7/46 ; C12N1/21 ; C12N15/87
摘要:
The present invention relates to a mutant microorganism, which is selected from the group consisting of genus Mannheimia, genus Actinobacillus and genus Anaerobiospirillum, producing homo-succinic acid and a method for producing homo-succinic acid using the same, and more particularly to a mutant microorganism producing succinic acid at a high concentration while producing little or no other organic acids in anaerobic conditions, which is obtained by disrupting a gene encoding lactate dehydrogenase (ldhA), a gene encoding phosphotransacetylase (pta), and a gene encoding acetate kinase (ackA), without disrupting a gene encoding pyruvate formate lyase (pfl), as well as a method for producing succinic acid using the same. The inventive mutant microorganism has the property of having a high growth rate and succinic acid productivity while producing little or no organic acids, as compared to the prior strains producing succinic acid. Thus, the inventive mutant microorganism is useful to produce succinic acid for industrial use.
公开/授权文献
信息查询