发明申请
- 专利标题: PYRAZOLE DERIVATIVES, MEDICINAL COMPOSITION CONTAINING THE SAME, MEDICINAL USE THEREOF, AND INTERMEDIATE FOR PRODUCTION THEREOF
- 专利标题(中): 吡唑衍生物,含有它们的药物组合物,药物用途及其生产中间体
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申请号: US12421236申请日: 2009-04-09
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公开(公告)号: US20090203633A1公开(公告)日: 2009-08-13
- 发明人: Nobuhiko Fushimi , Kazuo Shimizu , Shigeru Yonekubo , Hirotaka Teranishi , Masaki Tomae
- 申请人: Nobuhiko Fushimi , Kazuo Shimizu , Shigeru Yonekubo , Hirotaka Teranishi , Masaki Tomae
- 申请人地址: JP Nagano
- 专利权人: KISSEI PHARMACEUTICAL CO., LTD
- 当前专利权人: KISSEI PHARMACEUTICAL CO., LTD
- 当前专利权人地址: JP Nagano
- 优先权: JP244381/2002 20020823; JP324076/2002 20021107
- 主分类号: A61K31/7056
- IPC分类号: A61K31/7056
摘要:
The present invention provides pyrazole derivatives represented by the general formula: wherein R1 represents H, an optionally substituted C1-6 alkyl group etc.; one of Q and T represents a group represented by the general formula: or a group represented by the general formula: while the other represents an optionally substituted C1-6 alkyl group etc.; R2 represents H, a halogen atom, OH, an optionally substituted C1-6 alkyl group etc.; X represents a single bond, O or S; Y represents an optionally substituted C1-6 alkylene group etc.; Z represents —RB, —CORC etc. in which RB represents an optionally substituted C1-6 alkyl group etc.; and RC represents an optionally substituted C1-6 alkyl group etc.; R4 represents H, an optionally substituted C1-6 alkyl group etc.; and R3, R5 and R6 represent H, a halogen atom etc., pharmaceutically acceptable salts thereof or prodrugs thereof, which exhibit an excellent inhibitory activity in human SGLT1 and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, impaired glucose tolerance, impaired fasting glycemia, diabetic complications or obesity, and a disease associated with the increase of blood galactose level such as galactosemia, and pharmaceutical compositions comprising the same, pharmaceutical uses thereof, and intermediates for production thereof.
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