发明申请
US20090203648A1 Modified phosphocalcic compound, injectable composition containing same
有权
改性磷酸钙化合物，含有其的可注射组合物
- 专利标题： Modified phosphocalcic compound, injectable composition containing same
- 专利标题（中）： 改性磷酸钙化合物，含有其的可注射组合物
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申请号： US12385614申请日： 2009-04-14
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公开(公告)号： US20090203648A1公开(公告)日： 2009-08-13
- 发明人: Bruno Bujoli , Solen Josse , Jerome Guicheux , Pascal Janvier , Jean-Michel Bouler , Guy Daculsi
- 申请人： Bruno Bujoli , Solen Josse , Jerome Guicheux , Pascal Janvier , Jean-Michel Bouler , Guy Daculsi
- 申请人地址： FR Paris FR Nantes FR Paris
- 专利权人： Centre National de la Recherche Scientifique,Universite de Nantes,Institut National de la Sante et de la Recherche Medicale
- 当前专利权人： Centre National de la Recherche Scientifique,Universite de Nantes,Institut National de la Sante et de la Recherche Medicale
- 当前专利权人地址： FR Paris FR Nantes FR Paris
- 优先权： FR0202707 20020403
- 主分类号： A61K31/675
- IPC分类号： A61K31/675 ; C07F9/06 ; C07F9/58 ; C07F9/6506 ; A61K31/661 ; A61P19/10
摘要：
A phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to a suspension of a precursor phosphocalcic compound in ultras-pure water, while stirring the reaction medium at room temperature, then in recovering by centrifuging the formed compound. The compound is useful for making an injectable composition, for use in the treatment of bone remodeling equilibrium.