Methods are described for configuring a quantizer to achieve improved end-to-end distortion performance when transmitting encoded source data over a noisy channel. The codebook and partitioning are selected using an iterative process of determining an updated codebook and an updated partition space, where the updated codebook is based, in part, on the average symbol error probability of the channel. Complete knowledge of the transitional probabilities of the channel is not required. Variants of the iterative process are described.