发明申请
- 专利标题： FUSED AMINODIHYDROTHIAZINE DERIVATIVES
- 专利标题（中）： 熔融氨基二氢卟吩衍生物
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申请号： US12355154申请日： 2009-01-16
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公开(公告)号： US20090209755A1公开(公告)日： 2009-08-20
- 发明人: Yuichi SUZUKI , Takafumi MOTOKI , Toshihiko KANEKO , Mamoru TAKAISHI , Tasuku ISHIDA , Yoichi KITA , Kunitoshi TAKEDA , Noboru YAMAMOTO , Afzal KHAN , Paschalis DIMOPOULOS
- 申请人： Yuichi SUZUKI , Takafumi MOTOKI , Toshihiko KANEKO , Mamoru TAKAISHI , Tasuku ISHIDA , Yoichi KITA , Kunitoshi TAKEDA , Noboru YAMAMOTO , Afzal KHAN , Paschalis DIMOPOULOS
- 优先权： JP2008-008680 20080118; JP2008-197204 20080731
- 主分类号： C07D513/02
- IPC分类号： C07D513/02 ; C07D279/08
摘要：
A compound represented by the general formula: or a pharmaceutically acceptable salt thereof or a solvate thereof, wherein Ring A is a C6-14 aryl group or the like, L is —NReCO— or the like (wherein Re is a hydrogen atom or the like), Ring B is a C6-14 aryl group or the like, X is a C1-3 alkylene group or the like, Y is a single bond or the like, Z is a C1-3 alkylene group or the like, R1 and R2 are each independently a hydrogen atom or the like, and R3, R4, R5 and R6 are independently a hydrogen atom, a halogen atom or the like, has an Aβ production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ and typified by Alzheimer-type dementia.
公开/授权文献
- US08158620B2 Fused aminodihydrothiazine derivatives 公开/授权日：2012-04-17
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