A computer program product, apparatus, and method for handling early termination of an I/O operation at a channel subsystem in an I/O processing system are provided. The computer program product includes a tangible storage medium readable by a processing circuit and storing instructions for execution by the processing circuit for performing a method. The method includes receiving a request to terminate an I/O operation, and transmitting an abort command to a control unit in communication with the channel subsystem in response to receiving the request to terminate the I/O operation. The method also includes transmitting a purge path command to purge a path associated with the I/O operation, where the purge path command includes an error code identifying the request to terminate the I/O operation.