发明申请
US20090214477A1 Human Marker Genes and Agents for Diagnosis, Treatment and Prophylaxis of Cardiovascular Disorders and Artherosclerosis
审中-公开
人类基因和诊断，治疗和预防心血管疾病和动脉粥样硬化的代理
- 专利标题： Human Marker Genes and Agents for Diagnosis, Treatment and Prophylaxis of Cardiovascular Disorders and Artherosclerosis
- 专利标题（中）： 人类基因和诊断，治疗和预防心血管疾病和动脉粥样硬化的代理
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申请号： US11911528申请日： 2006-04-08
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公开(公告)号： US20090214477A1公开(公告)日： 2009-08-27
- 发明人: Ulrich Betz , Donatella D'Urso , Peter Kolkhof , Michael Seewald , Jochen Strayle , Anne Plötner , Michael Hannus
- 申请人： Ulrich Betz , Donatella D'Urso , Peter Kolkhof , Michael Seewald , Jochen Strayle , Anne Plötner , Michael Hannus
- 申请人地址： DE Dresden
- 专利权人： Cenix BioScience GmbH
- 当前专利权人： Cenix BioScience GmbH
- 当前专利权人地址： DE Dresden
- 国际申请： PCT/EP06/03219 WO 20060408
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C12Q1/02 ; G01N33/53 ; C12Q1/66 ; A61K31/7105 ; C12N15/63 ; C12Q1/68
摘要：
The invention relates to novel targets in the screening for compounds useful in the treatment and/or prophylaxis of a disease selected from the group comprising cardiovascular diseases, disorders of lipid metabolism or atherosclerosis. The invention relates to novel compounds for use as a medicament for diseases or conditions involving a disease selected from the group comprising cardiovascular diseases, disorders of lipid metabolism or atherosclerosis. The invention especially relates to antagonists and expression-inhibitory compounds that target G-protein coupled receptors (GPCRs), kinases and proteases, and to methods for identifying such compounds. The invention further relates to methods for identifying these antagonists and expression-inhibitory compounds, and methods for diagnosing a disease selected from the group comprising cardiovascular diseases, disorders of lipid metabolism or atherosclerosis or a susceptibility to such a condition.
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