发明申请
US20090215746A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINES AS CALCIUM RECEPTOR MODULATING AGENTS
审中-公开
作为钙受体调节剂的取代的吡唑并[1,5-A]嘧啶
- 专利标题: SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINES AS CALCIUM RECEPTOR MODULATING AGENTS
- 专利标题(中): 作为钙受体调节剂的取代的吡唑并[1,5-A]嘧啶
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申请号: US12263426申请日: 2008-10-31
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公开(公告)号: US20090215746A1公开(公告)日: 2009-08-27
- 发明人: Tsuneo Yasuma , Akira Mori , Masahiro Kawase , Hiroyuki Kimura , Masato Yoshida , Albert Charles Gyorkos , Scott Alan Pratt , Christopher Peter Corrette
- 申请人: Tsuneo Yasuma , Akira Mori , Masahiro Kawase , Hiroyuki Kimura , Masato Yoshida , Albert Charles Gyorkos , Scott Alan Pratt , Christopher Peter Corrette
- 申请人地址: JP Osaka
- 专利权人: Takeda Pharmaceuticals Company Limited
- 当前专利权人: Takeda Pharmaceuticals Company Limited
- 当前专利权人地址: JP Osaka
- 主分类号: A61K31/519
- IPC分类号: A61K31/519 ; A61K31/55 ; A61K31/541 ; A61K31/5377 ; C07D487/10 ; C07D487/04 ; A61P19/00
摘要:
There is provided a calcium receptor modulator comprising a compound of the formula (I): wherein ring A is an optionally substituted 5- to 7-membered ring; ring B is an optionally substituted 5- to 7-membered heterocyclic ring; X1 is CR1, CR1R2, N or NR13; X2 is N or NR3; Y is C, CR4 or N, Z is CR5, CR5R6, N or NR7; Ar is an optionally substituted cyclic group; R is H, an optionally substituted hydrocarbon group, etc.; and is a single bond or a double bond; R1, R2, R3, R4, R5, R6, R7 and R13 are independently H, an optionally substituted hydrocarbon group; or a salt thereof or a prodrug thereof. Compounds of the formula (II) and (III): wherein ring A is an optionally substituted 5- to 7-membered ring; Q is C, CR5 or N; R8, R9, R10, R11 and R12 are independently, H, an optionally substituted hydrocarbon group, etc., or a salt thereof are also provided.Also specify X1, R3, R1, Y and X3 in formula (II) and (III) as before.
公开/授权文献
- US1747122A Motor vehicle 公开/授权日:1930-02-11